Pulmonary embolism in patients with coronavirus disease-2019 (COVID-19) pneumonia: a narrative review.
Identifieur interne : 000829 ( Main/Exploration ); précédent : 000828; suivant : 000830Pulmonary embolism in patients with coronavirus disease-2019 (COVID-19) pneumonia: a narrative review.
Auteurs : Yasser Sakr [Allemagne] ; Manuela Giovini [Italie] ; Marc Leone [France] ; Giacinto Pizzilli [Italie] ; Andreas Kortgen [Allemagne] ; Michael Bauer [Allemagne] ; Tommaso Tonetti [Italie] ; Gary Duclos [France] ; Laurent Zieleskiewicz [France] ; Samuel Buschbeck [Allemagne] ; V Marco Ranieri [Italie] ; Elio Antonucci [Italie]Source :
- Annals of intensive care [ 2110-5820 ] ; 2020.
Abstract
BACKGROUND
Preliminary reports have described significant procoagulant events in patients with coronavirus disease-2019 (COVID-19), including life-threatening pulmonary embolism (PE).
MAIN TEXT
We review the current data on the epidemiology, the possible underlying pathophysiologic mechanisms, and the therapeutic implications of PE in relation to COVID-19. The incidence of PE is reported to be around 2.6-8.9% of COVID-19 in hospitalized patients and up to one-third of those requiring intensive care unit (ICU) admission, despite standard prophylactic anticoagulation. This may be explained by direct and indirect pathologic consequences of COVID-19, complement activation, cytokine release, endothelial dysfunction, and interactions between different types of blood cells.
CONCLUSION
Thromboprophylaxis should be started in all patients with suspected or confirmed COVID-19 admitted to the hospital. The use of an intermediate therapeutic dose of low molecular weight (LMWH) or unfractionated heparin can be considered on an individual basis in patients with multiple risk factors for venous thromboembolism, including critically ill patients admitted to the ICU. Decisions about extending prophylaxis with LMWH after hospital discharge should be made after balancing the reduced risk of venous thromboembolism (VTE) with the risk of increased bleeding events and should be continued for 7-14 days after hospital discharge or in the pre-hospital phase in case of pre-existing or persisting VTE risk factors. Therapeutic anticoagulation is the cornerstone in the management of patients with PE. Selection of an appropriate agent and correct dosing requires consideration of underlying comorbidities.
DOI: 10.1186/s13613-020-00741-0
PubMed: 32936400
Affiliations:
- Allemagne, France, Italie
- Provence-Alpes-Côte d'Azur, Émilie-Romagne
- Bologne, Marseille
- Université d'Aix-Marseille, Université de Bologne
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type="university">Université de Bologne</orgName><placeName><settlement type="city">Bologne</settlement><region nuts="2" type="region">Émilie-Romagne</region></placeName></affiliation></author><author><name sortKey="Duclos, Gary" sort="Duclos, Gary" uniqKey="Duclos G" first="Gary" last="Duclos">Gary Duclos</name><affiliation wicri:level="4"><nlm:affiliation>Service d'Anesthésie et de Réanimation, Aix Marseille Université, Assistance Publique Hôpitaux Universitaires de Marseille, Hôpital Nord, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service d'Anesthésie et de Réanimation, Aix Marseille Université, Assistance Publique Hôpitaux Universitaires de Marseille, Hôpital Nord, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName><orgName type="university">Université 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xml:lang="fr">Italie</country><wicri:regionArea>Dipartimento di Scienze Mediche e Chirurgiche, Anesthesia and Intensive Care Medicine, Alma Mater Studiorum, Università di Bologna, Policlinico di Sant'Orsola, Bologna</wicri:regionArea><orgName type="university">Université de Bologne</orgName><placeName><settlement type="city">Bologne</settlement><region nuts="2" type="region">Émilie-Romagne</region></placeName></affiliation></author><author><name sortKey="Antonucci, Elio" sort="Antonucci, Elio" uniqKey="Antonucci E" first="Elio" last="Antonucci">Elio Antonucci</name><affiliation wicri:level="1"><nlm:affiliation>Intermediate Care Unit, Emergency Department, Ospedale Guglielmo da Saliceto, Piacenza, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Intermediate Care Unit, Emergency Department, Ospedale Guglielmo da Saliceto, Piacenza</wicri:regionArea><wicri:noRegion>Piacenza</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32936400</idno><idno type="pmid">32936400</idno><idno type="doi">10.1186/s13613-020-00741-0</idno><idno type="wicri:Area/Main/Corpus">000111</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000111</idno><idno type="wicri:Area/Main/Curation">000111</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000111</idno><idno type="wicri:Area/Main/Exploration">000111</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Pulmonary embolism in patients with coronavirus disease-2019 (COVID-19) pneumonia: a narrative review.</title><author><name sortKey="Sakr, Yasser" sort="Sakr, Yasser" uniqKey="Sakr Y" first="Yasser" last="Sakr">Yasser Sakr</name><affiliation wicri:level="1"><nlm:affiliation>Dept. of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Am Klinikum 1, 07743, Jena, Germany. yasser.sakr@med.uni-jena.de.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Dept. of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Am Klinikum 1, 07743, Jena</wicri:regionArea><wicri:noRegion>07743, Jena</wicri:noRegion><wicri:noRegion>07743, Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion></affiliation></author><author><name sortKey="Giovini, Manuela" sort="Giovini, Manuela" uniqKey="Giovini M" first="Manuela" last="Giovini">Manuela Giovini</name><affiliation wicri:level="1"><nlm:affiliation>Intermediate Care Unit, Emergency Department, Ospedale Guglielmo da Saliceto, Piacenza, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Intermediate Care Unit, Emergency Department, Ospedale Guglielmo da Saliceto, Piacenza</wicri:regionArea><wicri:noRegion>Piacenza</wicri:noRegion></affiliation></author><author><name sortKey="Leone, Marc" sort="Leone, Marc" uniqKey="Leone M" first="Marc" last="Leone">Marc Leone</name><affiliation wicri:level="4"><nlm:affiliation>Service d'Anesthésie et de Réanimation, Aix Marseille Université, Assistance Publique Hôpitaux Universitaires de Marseille, Hôpital Nord, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service d'Anesthésie et de Réanimation, Aix Marseille Université, Assistance Publique Hôpitaux Universitaires de Marseille, Hôpital Nord, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName><orgName type="university">Université d'Aix-Marseille</orgName></affiliation></author><author><name sortKey="Pizzilli, Giacinto" sort="Pizzilli, Giacinto" uniqKey="Pizzilli G" first="Giacinto" last="Pizzilli">Giacinto Pizzilli</name><affiliation wicri:level="4"><nlm:affiliation>Dipartimento di Scienze Mediche e Chirurgiche, Anesthesia and Intensive Care Medicine, Alma Mater Studiorum, Università di Bologna, Policlinico di Sant'Orsola, Bologna, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Dipartimento di Scienze Mediche e Chirurgiche, Anesthesia and Intensive Care Medicine, Alma Mater Studiorum, Università di Bologna, Policlinico di Sant'Orsola, Bologna</wicri:regionArea><orgName type="university">Université de Bologne</orgName><placeName><settlement type="city">Bologne</settlement><region nuts="2" type="region">Émilie-Romagne</region></placeName></affiliation></author><author><name sortKey="Kortgen, Andreas" sort="Kortgen, Andreas" uniqKey="Kortgen A" first="Andreas" last="Kortgen">Andreas Kortgen</name><affiliation wicri:level="1"><nlm:affiliation>Dept. of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Am Klinikum 1, 07743, Jena, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Dept. of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Am Klinikum 1, 07743, Jena</wicri:regionArea><wicri:noRegion>07743, Jena</wicri:noRegion><wicri:noRegion>07743, Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion></affiliation></author><author><name sortKey="Bauer, Michael" sort="Bauer, Michael" uniqKey="Bauer M" first="Michael" last="Bauer">Michael Bauer</name><affiliation wicri:level="1"><nlm:affiliation>Dept. of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Am Klinikum 1, 07743, Jena, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Dept. of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Am Klinikum 1, 07743, Jena</wicri:regionArea><wicri:noRegion>07743, Jena</wicri:noRegion><wicri:noRegion>07743, Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion></affiliation></author><author><name sortKey="Tonetti, Tommaso" sort="Tonetti, Tommaso" uniqKey="Tonetti T" first="Tommaso" last="Tonetti">Tommaso Tonetti</name><affiliation wicri:level="4"><nlm:affiliation>Dipartimento di Scienze Mediche e Chirurgiche, Anesthesia and Intensive Care Medicine, Alma Mater Studiorum, Università di Bologna, Policlinico di Sant'Orsola, Bologna, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Dipartimento di Scienze Mediche e Chirurgiche, Anesthesia and Intensive Care Medicine, Alma Mater Studiorum, Università di Bologna, Policlinico di Sant'Orsola, Bologna</wicri:regionArea><orgName type="university">Université de Bologne</orgName><placeName><settlement type="city">Bologne</settlement><region nuts="2" type="region">Émilie-Romagne</region></placeName></affiliation></author><author><name sortKey="Duclos, Gary" sort="Duclos, Gary" uniqKey="Duclos G" first="Gary" last="Duclos">Gary Duclos</name><affiliation wicri:level="4"><nlm:affiliation>Service d'Anesthésie et de Réanimation, Aix Marseille Université, Assistance Publique Hôpitaux Universitaires de Marseille, Hôpital Nord, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service d'Anesthésie et de Réanimation, Aix Marseille Université, Assistance Publique Hôpitaux Universitaires de Marseille, Hôpital Nord, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName><orgName type="university">Université d'Aix-Marseille</orgName></affiliation></author><author><name sortKey="Zieleskiewicz, Laurent" sort="Zieleskiewicz, Laurent" uniqKey="Zieleskiewicz L" first="Laurent" last="Zieleskiewicz">Laurent Zieleskiewicz</name><affiliation wicri:level="4"><nlm:affiliation>Service d'Anesthésie et de Réanimation, Aix Marseille Université, Assistance Publique Hôpitaux Universitaires de Marseille, Hôpital Nord, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service d'Anesthésie et de Réanimation, Aix Marseille Université, Assistance Publique Hôpitaux Universitaires de Marseille, Hôpital Nord, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName><orgName type="university">Université d'Aix-Marseille</orgName></affiliation></author><author><name sortKey="Buschbeck, Samuel" sort="Buschbeck, Samuel" uniqKey="Buschbeck S" first="Samuel" last="Buschbeck">Samuel Buschbeck</name><affiliation wicri:level="1"><nlm:affiliation>Dept. of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Am Klinikum 1, 07743, Jena, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Dept. of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Am Klinikum 1, 07743, Jena</wicri:regionArea><wicri:noRegion>07743, Jena</wicri:noRegion><wicri:noRegion>07743, Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion></affiliation></author><author><name sortKey="Ranieri, V Marco" sort="Ranieri, V Marco" uniqKey="Ranieri V" first="V Marco" last="Ranieri">V Marco Ranieri</name><affiliation wicri:level="4"><nlm:affiliation>Dipartimento di Scienze Mediche e Chirurgiche, Anesthesia and Intensive Care Medicine, Alma Mater Studiorum, Università di Bologna, Policlinico di Sant'Orsola, Bologna, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Dipartimento di Scienze Mediche e Chirurgiche, Anesthesia and Intensive Care Medicine, Alma Mater Studiorum, Università di Bologna, Policlinico di Sant'Orsola, Bologna</wicri:regionArea><orgName type="university">Université de Bologne</orgName><placeName><settlement type="city">Bologne</settlement><region nuts="2" type="region">Émilie-Romagne</region></placeName></affiliation></author><author><name sortKey="Antonucci, Elio" sort="Antonucci, Elio" uniqKey="Antonucci E" first="Elio" last="Antonucci">Elio Antonucci</name><affiliation wicri:level="1"><nlm:affiliation>Intermediate Care Unit, Emergency Department, Ospedale Guglielmo da Saliceto, Piacenza, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Intermediate Care Unit, Emergency Department, Ospedale Guglielmo da Saliceto, Piacenza</wicri:regionArea><wicri:noRegion>Piacenza</wicri:noRegion></affiliation></author></analytic><series><title level="j">Annals of intensive care</title><idno type="ISSN">2110-5820</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b></p><p>Preliminary reports have described significant procoagulant events in patients with coronavirus disease-2019 (COVID-19), including life-threatening pulmonary embolism (PE).</p></div><div type="abstract" xml:lang="en"><p><b>MAIN TEXT</b></p><p>We review the current data on the epidemiology, the possible underlying pathophysiologic mechanisms, and the therapeutic implications of PE in relation to COVID-19. The incidence of PE is reported to be around 2.6-8.9% of COVID-19 in hospitalized patients and up to one-third of those requiring intensive care unit (ICU) admission, despite standard prophylactic anticoagulation. This may be explained by direct and indirect pathologic consequences of COVID-19, complement activation, cytokine release, endothelial dysfunction, and interactions between different types of blood cells.</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSION</b></p><p>Thromboprophylaxis should be started in all patients with suspected or confirmed COVID-19 admitted to the hospital. The use of an intermediate therapeutic dose of low molecular weight (LMWH) or unfractionated heparin can be considered on an individual basis in patients with multiple risk factors for venous thromboembolism, including critically ill patients admitted to the ICU. Decisions about extending prophylaxis with LMWH after hospital discharge should be made after balancing the reduced risk of venous thromboembolism (VTE) with the risk of increased bleeding events and should be continued for 7-14 days after hospital discharge or in the pre-hospital phase in case of pre-existing or persisting VTE risk factors. Therapeutic anticoagulation is the cornerstone in the management of patients with PE. Selection of an appropriate agent and correct dosing requires consideration of underlying comorbidities.</p></div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">32936400</PMID><DateRevised><Year>2020</Year><Month>09</Month><Day>17</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Print">2110-5820</ISSN><JournalIssue CitedMedium="Print"><Volume>10</Volume><Issue>1</Issue><PubDate><Year>2020</Year><Month>Sep</Month><Day>16</Day></PubDate></JournalIssue><Title>Annals of intensive care</Title><ISOAbbreviation>Ann Intensive Care</ISOAbbreviation></Journal><ArticleTitle>Pulmonary embolism in patients with coronavirus disease-2019 (COVID-19) pneumonia: a narrative review.</ArticleTitle><Pagination><MedlinePgn>124</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1186/s13613-020-00741-0</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Preliminary reports have described significant procoagulant events in patients with coronavirus disease-2019 (COVID-19), including life-threatening pulmonary embolism (PE).</AbstractText><AbstractText Label="MAIN TEXT" NlmCategory="UNASSIGNED">We review the current data on the epidemiology, the possible underlying pathophysiologic mechanisms, and the therapeutic implications of PE in relation to COVID-19. The incidence of PE is reported to be around 2.6-8.9% of COVID-19 in hospitalized patients and up to one-third of those requiring intensive care unit (ICU) admission, despite standard prophylactic anticoagulation. This may be explained by direct and indirect pathologic consequences of COVID-19, complement activation, cytokine release, endothelial dysfunction, and interactions between different types of blood cells.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Thromboprophylaxis should be started in all patients with suspected or confirmed COVID-19 admitted to the hospital. The use of an intermediate therapeutic dose of low molecular weight (LMWH) or unfractionated heparin can be considered on an individual basis in patients with multiple risk factors for venous thromboembolism, including critically ill patients admitted to the ICU. Decisions about extending prophylaxis with LMWH after hospital discharge should be made after balancing the reduced risk of venous thromboembolism (VTE) with the risk of increased bleeding events and should be continued for 7-14 days after hospital discharge or in the pre-hospital phase in case of pre-existing or persisting VTE risk factors. Therapeutic anticoagulation is the cornerstone in the management of patients with PE. Selection of an appropriate agent and correct dosing requires consideration of underlying comorbidities.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Sakr</LastName><ForeName>Yasser</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Dept. of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Am Klinikum 1, 07743, Jena, Germany. yasser.sakr@med.uni-jena.de.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Giovini</LastName><ForeName>Manuela</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Intermediate Care Unit, Emergency Department, Ospedale Guglielmo da Saliceto, Piacenza, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Leone</LastName><ForeName>Marc</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Service d'Anesthésie et de Réanimation, Aix Marseille Université, Assistance Publique Hôpitaux Universitaires de Marseille, Hôpital Nord, Marseille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pizzilli</LastName><ForeName>Giacinto</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Dipartimento di Scienze Mediche e Chirurgiche, Anesthesia and Intensive Care Medicine, Alma Mater Studiorum, Università di Bologna, Policlinico di Sant'Orsola, Bologna, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kortgen</LastName><ForeName>Andreas</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Dept. of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Am Klinikum 1, 07743, Jena, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bauer</LastName><ForeName>Michael</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Dept. of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Am Klinikum 1, 07743, Jena, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tonetti</LastName><ForeName>Tommaso</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Dipartimento di Scienze Mediche e Chirurgiche, Anesthesia and Intensive Care Medicine, Alma Mater Studiorum, Università di Bologna, Policlinico di Sant'Orsola, Bologna, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Duclos</LastName><ForeName>Gary</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Service d'Anesthésie et de Réanimation, Aix Marseille Université, Assistance Publique Hôpitaux Universitaires de Marseille, Hôpital Nord, Marseille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zieleskiewicz</LastName><ForeName>Laurent</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Service d'Anesthésie et de Réanimation, Aix Marseille Université, Assistance Publique Hôpitaux Universitaires de Marseille, Hôpital Nord, Marseille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Buschbeck</LastName><ForeName>Samuel</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Dept. of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Am Klinikum 1, 07743, Jena, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ranieri</LastName><ForeName>V Marco</ForeName><Initials>VM</Initials><AffiliationInfo><Affiliation>Dipartimento di Scienze Mediche e Chirurgiche, Anesthesia and Intensive Care Medicine, Alma Mater Studiorum, Università di Bologna, Policlinico di Sant'Orsola, Bologna, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Antonucci</LastName><ForeName>Elio</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Intermediate Care Unit, Emergency Department, Ospedale Guglielmo da Saliceto, Piacenza, Italy.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>09</Month><Day>16</Day></ArticleDate></Article><MedlineJournalInfo><Country>Germany</Country><MedlineTA>Ann Intensive Care</MedlineTA><NlmUniqueID>101562873</NlmUniqueID><ISSNLinking>2110-5820</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">COVID-19</Keyword><Keyword MajorTopicYN="N">Pulmonary embolism</Keyword><Keyword MajorTopicYN="N">SARS-CoV-2</Keyword><Keyword MajorTopicYN="N">Thromboprophylaxis</Keyword><Keyword MajorTopicYN="N">Venous thromboembolism</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>05</Month><Day>25</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>09</Month><Day>06</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>9</Month><Day>16</Day><Hour>12</Hour><Minute>16</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>9</Month><Day>17</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>9</Month><Day>17</Day><Hour>6</Hour><Minute>1</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32936400</ArticleId><ArticleId IdType="doi">10.1186/s13613-020-00741-0</ArticleId><ArticleId IdType="pii">10.1186/s13613-020-00741-0</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Allemagne</li><li>France</li><li>Italie</li></country><region><li>Provence-Alpes-Côte d'Azur</li><li>Émilie-Romagne</li></region><settlement><li>Bologne</li><li>Marseille</li></settlement><orgName><li>Université d'Aix-Marseille</li><li>Université de Bologne</li></orgName></list><tree><country name="Allemagne"><noRegion><name sortKey="Sakr, Yasser" sort="Sakr, Yasser" uniqKey="Sakr Y" first="Yasser" last="Sakr">Yasser Sakr</name></noRegion><name sortKey="Bauer, Michael" sort="Bauer, Michael" uniqKey="Bauer M" first="Michael" last="Bauer">Michael Bauer</name><name sortKey="Buschbeck, Samuel" sort="Buschbeck, Samuel" uniqKey="Buschbeck S" first="Samuel" last="Buschbeck">Samuel Buschbeck</name><name sortKey="Kortgen, Andreas" sort="Kortgen, Andreas" uniqKey="Kortgen A" first="Andreas" last="Kortgen">Andreas Kortgen</name></country><country name="Italie"><noRegion><name sortKey="Giovini, Manuela" sort="Giovini, Manuela" uniqKey="Giovini M" first="Manuela" last="Giovini">Manuela Giovini</name></noRegion><name sortKey="Antonucci, Elio" sort="Antonucci, Elio" uniqKey="Antonucci E" first="Elio" last="Antonucci">Elio Antonucci</name><name sortKey="Pizzilli, Giacinto" sort="Pizzilli, Giacinto" uniqKey="Pizzilli G" first="Giacinto" last="Pizzilli">Giacinto Pizzilli</name><name sortKey="Ranieri, V Marco" sort="Ranieri, V Marco" uniqKey="Ranieri V" first="V Marco" last="Ranieri">V Marco Ranieri</name><name sortKey="Tonetti, Tommaso" sort="Tonetti, Tommaso" uniqKey="Tonetti T" first="Tommaso" last="Tonetti">Tommaso Tonetti</name></country><country name="France"><region name="Provence-Alpes-Côte d'Azur"><name sortKey="Leone, Marc" sort="Leone, Marc" uniqKey="Leone M" first="Marc" last="Leone">Marc Leone</name></region><name sortKey="Duclos, Gary" sort="Duclos, Gary" uniqKey="Duclos G" first="Gary" last="Duclos">Gary Duclos</name><name sortKey="Zieleskiewicz, Laurent" sort="Zieleskiewicz, Laurent" uniqKey="Zieleskiewicz L" first="Laurent" last="Zieleskiewicz">Laurent Zieleskiewicz</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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